|
KMID : 0191120140290020248
|
|
Journal of Korean Medical Science
2014 Volume.29 No. 2 p.248 ~ p.253
|
|
|
Clinical Characteristics and Outcomes of Acute Hepatitis A in Korea: A Nationwide Multicenter Study
|
|
Kwon So-Young
Park Sang-Hoon
Yeon Jong-Eun
Jeong Sook-Hyang
Kwon Oh-Sang
Lee Jin-Woo
Kim Hong-Soo
Seo Yeon-Seok
Kim Young-Seok
Sohn Joo-Hyun
Yim Hyung-Joon
Choi Jong-Young
Lee Myung-Seok
Kweon Young-Oh
Cheong Jae-Youn
Kim Haak-Cheoul
Lee Heon-Ju
Baik Soon-Koo
An Hyong-Gin
Byun Kwan-Soo
|
|
|
Abstract
|
|
|
|
The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea.
|
|
|
KEYWORD
|
|
|
Hepatitis A, Morbidity, Mortality
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|